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Oncogenic RAS mutants confer resistance of rhabdomyosarcoma cells to oxidative stress-induced ferroptotic cell death

Recent genomic studies revealed a high rate of recurrent mutations in the RAS pathway in primary rhabdomyosarcoma (RMS) samples. In the present study, we therefore investigated how oncogenic RAS mutants impinge on the regulation of cell death of RMS cells. Here, we report that ectopic expression of...

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Main Authors: Christina eSchott, Ulrike eGraab, Nicole eCuvelier, Heidi eHahn, Simone eFulda
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Oncology
Subjects:
Apoptosis
Cell Death
Rhabdomyosarcoma
Ras
ROS
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00131/full
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