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Hedgehog inhibitor sonidegib potentiates 177Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude mice

Abstract Background 177Lu-octreotate can be used to treat somatostatin receptor expressing neuroendocrine tumors. It is highly effective in animal models, but clinical studies have so far only demonstrated low cure rates. Hedgehog inhibitors have shown therapeutic effect as monotherapy in neuroendoc...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Johan Spetz, Britta Langen, Nils Rudqvist, Toshima Z. Parris, Khalil Helou, Ola Nilsson, Eva Forssell-Aronsson
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2017-08-01
Schriftenreihe:BMC Cancer
Schlagworte:
Radionuclide therapy
radiation biology
Odomzo
LDE225
177Lu-DOTATATE
GEPNET
Online-Zugang:http://link.springer.com/article/10.1186/s12885-017-3524-x
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