Co-occurrence of transcriptionally distinct persister cell states underpins neoadjuvant therapy resistance in triple‑negative breast cancer

Abstract Background Although the addition of neoadjuvant immune checkpoint blockade to chemotherapy has improved patient outcome in early triple‑negative breast cancer (TNBC), some patients continue to have poor disease outcomes. Methods To characterise neoadjuvant chemotherapy (NAC) resistant cell...

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Principais autores:	Yu Zhang, Fatemeh Ahmadi Moughari, Ioanna Mavrommati, Nora J. Doleschall, Kate Moore, Gareth Muirhead, Ram Rajaram Srinivasan, Ping Gong, Jonathan T. Lei, Amy Fleming, Hwei Minn Khoo, Naomi Guppy, Gabrielle Elshtein, Mohammed Inayatullah, Vijay K. Tiwari, Lacey E. Dobrolecki, Michael T. Lewis, Syed Haider, Rachael Natrajan
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2026-04-01
Series:	Genome Medicine
Assuntos:	Triple-negative breast cancer Residual disease Neoadjuvant chemotherapy resistance Drug-tolerant persister cells KDM5B Hypoxia
Acceso en liña:	https://doi.org/10.1186/s13073-026-01643-9
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