Hypoxia at 3D organoid establishment selects essential subclones within heterogenous pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is especially hypoxic and composed of heterogeneous cell populations containing hypoxia-adapted cells. Hypoxia as a microenvironment of PDAC is known to cause epithelial-mesenchymal transition (EMT) and resistance to therapy. Therefore, cells adapted to hypoxi...

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Xehetasun bibliografikoak

Egile Nagusiak:	Koichiro Kumano, Hiromitsu Nakahashi, Pakavarin Louphrasitthiphol, Yukihito Kuroda, Yoshihiro Miyazaki, Osamu Shimomura, Shinji Hashimoto, Yoshimasa Akashi, Bryan J. Mathis, Jaejeong Kim, Yohei Owada, Colin R. Goding, Tatsuya Oda
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2024-02-01
Saila:	Frontiers in Cell and Developmental Biology
Gaiak:	3D organoid pancreatic cancer hypoxia tumor heterogeneity selection bias
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1327772/full
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!