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Structural insight into the tetramerization of an iterative ketoreductase siam through aromatic residues in the interfaces.

In the biosynthesis of polyketides, ketoreductases (KRs) are an important group of enzymes that determine the chiralities of the carbon backbones. SiaM is a special member of this group that can recognize substrates with different lengths and can be used iteratively. Here we report the crystal struc...

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Principais autores: Hua Wang, Huaidong Zhang, Yi Zou, Yanling Mi, Shuangjun Lin, Zhixiong Xie, Yunjun Yan, Houjin Zhang
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Acceso en liña:http://europepmc.org/articles/PMC4046962?pdf=render
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