A multifunctional ICAM1-directed MnO₂@ZIF8 nanoplatform with Tanshinone IIA synergistically reverses senescence and restores alveolar regeneration in septic lung injury

Abstract Sepsis-induced acute lung injury (ALI) is characterized by severe oxidative stress and senescence of alveolar type II epithelial cells (AECⅡ), yet effective therapies capable of reversing these pathological processes remain lacking. We developed a multifunctional ICAM1-targeted MnO2@ZIF8 na...

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मुख्य लेखकों:	Shan Lin, Xuefeng Ding, Xin Dang, Dachen Luo, Dan Cao, Zonglian Gong, Qingyuan Zhan
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	BMC 2026-04-01
श्रृंखला:	Journal of Nanobiotechnology
विषय:	Sepsis Acute Lung Injury Alveolar Epithelial Cells Type II Senescence Nanozyme
ऑनलाइन पहुंच:	https://doi.org/10.1186/s12951-026-04362-w
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