Molecular dynamics insights into the redox effects on PD-1/PD-L1 and PD-1/PD-L2 interactions

Abstract The PD-1/PD-L1/PD-L2 immune checkpoint plays a critical role in regulating immune responses, and its dysfunction is implicated in immune evasion by cancer cells. Cold atmospheric plasma (CAP) has emerged as a promising cancer therapeutic modality with the potential to modulate immune checkp...

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Bibliografiske detaljer

Principais autores:	Rasulbek Mashalov, Zulfizar Toshpulatova, Zhitong Chen, Jamoliddin Razzokov
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2025-09-01
Serier:	Scientific Reports
Fag:	Immune checkpoint proteins PD-1-PD-L1/PD-L2 Umbrella sampling Immunogenic cell death Potential mean force
Online adgang:	https://doi.org/10.1038/s41598-025-12902-x
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