Predicted Hotspot Residues Involved in Allosteric Signal Transmission in Pro-Apoptotic Peptide—Mcl1 Complexes

Mcl1 is a primary member of the Bcl–2 family—anti–apoptotic proteins (AAP)—that is overexpressed in several cancer pathologies. The apoptotic regulation is mediated through the binding of pro-apoptotic peptides (PAPs) (e.g., Bak and Bid) at the canonical hydrophobic binding groove (CBG) of Mcl1. Alt...

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Bibliografiske detaljer

Principais autores:	Parthiban Marimuthu, Jamoliddin Razzokov, Kalaimathy Singaravelu, Annemie Bogaerts
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2020-07-01
Serier:	Biomolecules
Fag:	B-cell lymphoma 2 myeloid cell leukemia binding free energy protein interaction network allosteric-signaling pathway
Online adgang:	https://www.mdpi.com/2218-273X/10/8/1114
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