In Vivo Evolution of Lacticaseibacillus rhamnosus GG Leads to Prolonged Persistence in the Digestive Tract

ABSTRACT This study explored in vivo evolution as a method to generate evolutionary clones of Lacticaseibacillus rhamnosus GG, a renowned probiotic organism found in many food supplements, with improved persistence in the intestinal tract. L. rhamnosus GG was autologously gavaged to mice and subsequ...

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Autors principals: Alexander Mark, Lorenzo Tosi, Lamia Chkaiban, Raphaela Bento, Biju Parekkadan
Format: Artigo
Idioma:Inglês
Publicat: Wiley 2025-03-01
Col·lecció:Food Bioengineering
Matèries:
intestinal drug delivery
microbiome
probiotics
strain engineering
Accés en línia:https://doi.org/10.1002/fbe2.70002
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