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3213 Unraveling the role of Phospholamban (PLN) in humans via the characterization of Induced Pluripotent Stem Cell (iPSC) Cardiomyocytes (CM) derived from carriers of a lethal PLN mutation

OBJECTIVES/SPECIFIC AIMS: To study the biology of Phosholamban (PLN) in a human relevant model. METHODS/STUDY POPULATION: State of the art stem-cell technologies using iPSC-CMs derived from carriers of a lethal PLN mutation. RESULTS/ANTICIPATED RESULTS: Our preliminary data demonstrate that this par...

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Principais autores: Maria Giovanna Trivieri, Francesca Stillitano, Delaine Ceholski, Irene Turnbull, Kevin Costa, Thomas Weber, Kenneth Fish, Evangelia Kranias, Roger Hajjar
Formato: Artigo
Idioma:Inglês
Publicado: Cambridge University Press 2019-03-01
Series:Journal of Clinical and Translational Science
Acceso en liña:https://www.cambridge.org/core/product/identifier/S2059866119000621/type/journal_article
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