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LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-κB/RELT signal pathway

Abstract Background Leukocyte Ig-like receptor B family 4 (LILRB4) as an immune checkpoint on myeloid cells is a potential target for tumor therapy. Extensive osteolytic bone lesion is the most characteristic feature of multiple myeloma. It is unclear whether ectopic LILRB4 on multiple myeloma regul...

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Principais autores: Hongying Wang, Lei Wang, Huiwen Luan, Jing Xiao, Zhiling Zhao, Pengfei Yu, Mi Deng, Yifan Liu, Shuhao Ji, Junjie Ma, Yan Zhou, Jiashen Zhang, Xianhui Meng, Juan Zhang, Xinyu Zhao, Chunling Li, Fangmin Li, Dapeng Wang, Shujuan Wei, Lijun Hui, Siman Nie, Changzhu Jin, Zhiqiang An, Ningyan Zhang, Yaopeng Wang, Cheng Cheng Zhang, Zunling Li
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-07-01
coleção:Journal of Experimental & Clinical Cancer Research
Assuntos:
LILRB4
Multiple myeloma
Bone lesion
RELT
Acesso em linha:https://doi.org/10.1186/s13046-024-03110-y
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