Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides

Abstract Bioactive peptides are key molecules in health and medicine. Deep learning holds a big promise for the discovery and design of bioactive peptides. Yet, suitable experimental approaches are required to validate candidates in high throughput and at low cost. Here, we established a cell-free p...

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Autors principals:	Amir Pandi, David Adam, Amir Zare, Van Tuan Trinh, Stefan L. Schaefer, Marie Burt, Björn Klabunde, Elizaveta Bobkova, Manish Kushwaha, Yeganeh Foroughijabbari, Peter Braun, Christoph Spahn, Christian Preußer, Elke Pogge von Strandmann, Helge B. Bode, Heiner von Buttlar, Wilhelm Bertrams, Anna Lena Jung, Frank Abendroth, Bernd Schmeck, Gerhard Hummer, Olalla Vázquez, Tobias J. Erb
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2023-11-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-023-42434-9
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