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Resolving the Haplotype Complexity of Colorectal Cancer Genomes with Droplet Barcode Sequencing

Precision medicine is increasingly applied in the cancer clinic, adapting treatment to genomic alterations of the tumor. However, whether alterations disrupt the function of a protein can depend on if both alleles of a gene are altered. While massively parallel sequencing technologies can identify s...

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Principais autores: Humam Siga, Pontus Höjer, Parham Pourbozorgi, Hooman Aghelpasand, Max Käller, Johan Hartman, Cecilia Williams, Afshin Ahmadian
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-05-01
Serier:Life
Fag:
cancer genomics
colorectal cancer
CRC
linked-reads
haplotyping
droplet barcode sequencing
Online adgang:https://www.mdpi.com/2075-1729/16/6/874
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