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Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes

BACKGROUND Low-dose anti–thymocyte globulin (ATG) transiently preserves C-peptide and lowers HbA1c in individuals with recent-onset type 1 diabetes (T1D); however, the mechanisms of action and features of the response remain unclear. Here, we characterized the post hoc immunological outcomes of ATG...

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Principais autores: Laura M. Jacobsen, Kirsten Diggins, Lori Blanchfield, James McNichols, Daniel J. Perry, Jason Brant, Xiaoru Dong, Rhonda Bacher, Vivian H. Gersuk, Desmond A. Schatz, Mark A. Atkinson, Clayton E. Mathews, Michael J. Haller, S. Alice Long, Peter S. Linsley, Todd M. Brusko
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical investigation 2023-08-01
Series:JCI Insight
Assuntos:
Endocrinology
Immunology
Acceso en liña:https://doi.org/10.1172/jci.insight.161812
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