The main steps of TCR signalingNegative times negative equals positive, THEMIS sets the rule on thymic selection and peripheral T cell responses

The activity of T cells is finely controlled by a set of negative regulators of T-cell antigen receptor (TCR)-mediated signaling. However, how those negative regulators are themselves controlled to prevent ineffective TCR-mediated responses remain poorly understood. Thymocyte-expressed molecule invo...

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Bibliographic Details

Main Authors:	Suzanne Mélique, Cui Yang, Renaud Lesourne
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2022-04-01
Series:	Biomedical Journal
Subjects:	Adaptive immunity T cells Signaling TCR T cell development
Online Access:	http://www.sciencedirect.com/science/article/pii/S2319417022000373
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