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Development and in vivo pharmacokinetic evaluation of a phospholipid complex self-nanoemulsifying drug delivery system (PLC-SNEDDS) for enhanced oral bioavailability of cannabidiol

Cannabidiol (CBD) exhibits poor oral bioavailability (approximately 6%) due to low solubility and excessive first-pass metabolism, limiting its therapeutic potential. This study introduces a novel phospholipid complex self-nanoemulsifying drug delivery system (CBD-PLC-SNEDDS) to enhance CBD delivery...

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Autores principales: Thabata Muta, Songhita Mukhopadhyay, Benjamin Noll, Yunmei Song, Sanjay Garg
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis Group 2026-12-01
Colección:Drug Delivery
Materias:
Cannabidiol
oral bioavailability
phospholipid complex
pharmacokinetics
self-nanoemulsifying drug delivery system
Acceso en línea:https://www.tandfonline.com/doi/10.1080/10717544.2026.2702143
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