Development and in vivo pharmacokinetic evaluation of a phospholipid complex self-nanoemulsifying drug delivery system (PLC-SNEDDS) for enhanced oral bioavailability of cannabidiol

Cannabidiol (CBD) exhibits poor oral bioavailability (approximately 6%) due to low solubility and excessive first-pass metabolism, limiting its therapeutic potential. This study introduces a novel phospholipid complex self-nanoemulsifying drug delivery system (CBD-PLC-SNEDDS) to enhance CBD delivery...

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Principais autores:	Thabata Muta, Songhita Mukhopadhyay, Benjamin Noll, Yunmei Song, Sanjay Garg
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis Group 2026-12-01
Series:	Drug Delivery
Assuntos:	Cannabidiol oral bioavailability phospholipid complex pharmacokinetics self-nanoemulsifying drug delivery system
Acceso en liña:	https://www.tandfonline.com/doi/10.1080/10717544.2026.2702143
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