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Incretin-like effects of small molecule trace amine-associated receptor 1 agonists

Objective: Type 2 diabetes and obesity are emerging pandemics in the 21st century creating worldwide urgency for the development of novel and safe therapies. We investigated trace amine-associated receptor 1 (TAAR1) as a novel target contributing to the control of glucose homeostasis and body weight...

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Principais autores: Susanne Raab, Haiyan Wang, Sabine Uhles, Nadine Cole, Ruben Alvarez-Sanchez, Basil Künnecke, Christoph Ullmer, Hugues Matile, Marc Bedoucha, Roger D. Norcross, Nickki Ottaway-Parker, Diego Perez-Tilve, Karin Conde Knape, Matthias H. Tschöp, Marius C. Hoener, Sabine Sewing
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016-01-01
coleção:Molecular Metabolism
Assuntos:
Pancreatic β-cell
Insulin secretion
Type 2 diabetes
Incretin hormones
Obesity
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2212877815002008
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