Comparing regional brain uptake of incretin receptor agonists after intranasal delivery in CD-1 mice and the APP/PS1 mouse model of Alzheimer’s disease

Abstract Targeting brain insulin resistance (BIR) has become an attractive alternative to traditional therapeutic treatments for Alzheimer’s disease (AD). Incretin receptor agonists (IRAs), targeting either or both of the glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypepti...

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Hlavní autoři:	Noor Abdulhameed, Alice Babin, Kim Hansen, Riley Weaver, William A. Banks, Konrad Talbot, Elizabeth M. Rhea
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-08-01
Edice:	Alzheimer’s Research & Therapy
Témata:	Incretin receptor agonist Intranasal Alzheimer’s disease GLP-1 Insulin signaling
On-line přístup:	https://doi.org/10.1186/s13195-024-01537-1
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