Activation of PERK/eIF2α/ATF4 signaling inhibits ERα expression in breast cancer

Approximately 70–80% of breast cancers rely on estrogen receptor alpha (ERα) for growth. The unfolded protein response (UPR), a cellular response to endoplasmic reticulum stress (ERS), is an important process crucial for oncogenic transformation. The effect of ERS on ERα expression and signaling rem...

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Auteurs principaux:	Yuanli Wu, Gang Wang, Ruixue Yang, Duanfang Zhou, Qingjuan Chen, Qiuya Wu, Bo Chen, Lie Yuan, Na Qu, Hongmei Wang, Moustapha Hassan, Ying Zhao, Mingpu Liu, Zhengze Shen, Weiying Zhou
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2025-07-01
Collection:	Neoplasia: An International Journal for Oncology Research
Sujets:	Breast cancer ESR1 ERα Endoplasmic reticulum stress Unfolded protein response ATF4
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S1476558625000442
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