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Adiposity, metabolites and endometrial cancer risk: inference from combinations of Mendelian randomization and observational analyses

Abstract Introduction The associations between excess adiposity and endometrial cancer (EC) risk may be mediated by altered metabolic profiles. Here, we triangulated evidence from observational and Mendelian randomisation (MR) analyses to investigate the relationship between adiposity traits, circul...

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Principais autores: Matthew A. Lee, Vanessa Y. Tan, Dimitri J. Pournaras, Sabrina Wang, Laure Dossus, Marc J. Gunter, Kaitlin H. Wade, Laura J. Corbin, Nicholas J. Timpson
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-10-01
Serier:BMC Cancer
Fag:
Adiposity
Metabolites
Endometrial cancer
Mendelian randomization
Online adgang:https://doi.org/10.1186/s12885-025-14756-y
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