L-NAME releases nitric oxide and potentiates subsequent nitroglycerin-mediated vasodilation

L-NG-Nitro arginine methyl ester (L-NAME) has been widely applied for several decades in both basic and clinical research as an antagonist of nitric oxide synthase (NOS). Herein, we show that L-NAME slowly releases NO from its guanidino nitro group. Daily pretreatment of rats with L-NAME potentiated...

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Principais autores:	Taiming Liu, Meijuan Zhang, George T. Mukosera, Dan Borchardt, Qian Li, Trent E. Tipple, Abu Shufian Ishtiaq Ahmed, Gordon G. Power, Arlin B. Blood
格式:	Artigo
语言:	Inglês
出版:	Elsevier 2019-09-01
丛编:	Redox Biology
在线阅读:	http://www.sciencedirect.com/science/article/pii/S2213231719303945
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