Mesenchymal stem cells protect the integrity of the alveolar epithelial barrier through extracellular vesicles by inhibiting MAPK-mediated necroptosis

Abstract Background Alveolar‒capillary barrier disruption is a hallmark of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). The contribution of necroptosis to the compromised alveolar-barrier in ALI remains unclear. Mesenchymal stem cells (MSCs) may contribute to tissue repair...

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Ngā kaituhi matua:	Tao Ruan, Jiaming Han, Chengxu Xue, Fengyuan Wang, Juntang Lin
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2025-05-01
Rangatū:	Stem Cell Research & Therapy
Ngā marau:	Acute lung injury Mesenchymal stem cells Alveolar epithelial barrier Tight junctions Necroptosis
Urunga tuihono:	https://doi.org/10.1186/s13287-025-04388-1
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!