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LAT4 drives temozolomide induced radiotherapy resistance in glioblastoma by enhancing mTOR pathway activation

Abstract Background Glioblastoma multiforme (GBM) represents the most prevalent form of primary malignant tumor within the central nervous system. The emergence of resistance to radiotherapy and chemotherapy represents a significant impediment to advancements in glioma treatment. Methods We establis...

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Principais autores: Wenrui Zang, Yangwu Liu, Jiajun Zheng, Yifeng Huang, Lei Chen, Chiyang Li, Jiakun Zhao, Qiang Zhou, Yangheng Xu, Zhenyuan Wang, Yongfu Cao, Wanling Zhang, Junjie Li, Yuntao Lu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-12-01
coleção:Cancer Cell International
Assuntos:
GBM
TMZ
Radiotherapy
LAT4
Amino acid metabolism
mTOR pathway
Acesso em linha:https://doi.org/10.1186/s12935-024-03590-0
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