LAT4 drives temozolomide induced radiotherapy resistance in glioblastoma by enhancing mTOR pathway activation

Abstract Background Glioblastoma multiforme (GBM) represents the most prevalent form of primary malignant tumor within the central nervous system. The emergence of resistance to radiotherapy and chemotherapy represents a significant impediment to advancements in glioma treatment. Methods We establis...

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Podrobná bibliografie

Hlavní autoři:	Wenrui Zang, Yangwu Liu, Jiajun Zheng, Yifeng Huang, Lei Chen, Chiyang Li, Jiakun Zhao, Qiang Zhou, Yangheng Xu, Zhenyuan Wang, Yongfu Cao, Wanling Zhang, Junjie Li, Yuntao Lu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-12-01
Edice:	Cancer Cell International
Témata:	GBM TMZ Radiotherapy LAT4 Amino acid metabolism mTOR pathway
On-line přístup:	https://doi.org/10.1186/s12935-024-03590-0
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