USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA.
Mediator of IRF3 activation (MITA, also known as stimulator of interferon genes, STING) senses the second messenger cyclic GMP-AMP (cGAMP) which is synthesized upon DNA virus infection and activates innate antiviral immune response. It has been demonstrated that the activity of MITA is delicately re...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science (PLoS)
2020-01-01
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| Collection: | PLoS Pathogens |
| Accès en ligne: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1008178&type=printable |
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