TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking

Summary: Mediator of IRF3 activation (MITA), also known as stimulator of interferon genes (STING), plays a vital role in the innate immune responses to cytosolic dsDNA. The trafficking of MITA from the ER to perinuclear vesicles is necessary for its activation of the downstream molecules, which lead...

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Detalhes bibliográficos

Principais autores:	Ming-Shun Sun, Jie Zhang, Li-Qun Jiang, Yi-Xi Pan, Jiao-Yi Tan, Fang Yu, Lin Guo, Lei Yin, Chao Shen, Hong-Bing Shu, Yu Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2018-12-01
coleção:	Cell Reports
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124718318114
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