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DNA methylation at individual CpG-sites of EPB41L3, HTERT and FAM19A4 are useful for detection of cervical high-grade squamous intraepithelial lesions (HSIL) or worse: Analysis of individual CpG-sites outperforms averaging

Global methylation analysis of gene promoters is promising for detection of high-grade squamous intraepithelial lesions or worse (HSIL+) in high-risk human papillomavirus (hrHPV)-positive women. However, diagnostic performance of methylation data at individual CpG-sites is limited. We explored methy...

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Principais autores: Monica Molano, Dorothy A. Machalek, Samuel Phillips, Grace Tan, Suzanne M. Garland, David Hawkes, Prisha Balgovind, Reza Haqshenas, Steve G. Badman, John Bolnga, Josephine Gabuzzi, Zure Kombati, Gloria M. Munnull, Julia ML. Brotherton, Marion Saville, John M. Kaldor, Pamela J. Toliman, Andrew J. Vallely, Gerald L. Murray
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-12-01
coleção:Tumour Virus Research
Assuntos:
DNA methylation
Cervical cancer
Human papillomavirus
Diagnostic test
Epigenetics
Molecular diagnostics
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2666679024000120
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