Endogenous tetrahydrobiopterin in humans: circadian rhythm, sex, race, age, and disease status
Introduction6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for multiple enzymes, including phenylalanine hydroxylase (PAH). Exogenous BH4, or its natural precursor sepiapterin, is utilized to treat patients with phenylketonuria (PKU), a disease caused by PAH deficiency. This...
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| Formáid: | Artigo |
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Frontiers Media S.A.
2025-12-01
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| Sraith: | Frontiers in Pharmacology |
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| Rochtain ar líne: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1701617/full |
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