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Endogenous tetrahydrobiopterin in humans: circadian rhythm, sex, race, age, and disease status

Introduction6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for multiple enzymes, including phenylalanine hydroxylase (PAH). Exogenous BH4, or its natural precursor sepiapterin, is utilized to treat patients with phenylketonuria (PKU), a disease caused by PAH deficiency. This...

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Päätekijät: Lan Gao, Neil Smith, Ronald Kong
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2025-12-01
Sarja:Frontiers in Pharmacology
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Linkit:https://www.frontiersin.org/articles/10.3389/fphar.2025.1701617/full
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