Trdn-as directs m6A-dependent transcriptional termination for accurate triadin isoform switching, preventing aberrant dyads and cardiomyopathy

Abstract Heart failure is a leading cause of mortality, and impaired cardiac excitation-contraction coupling represents a potentially fatal trigger for myocardial dysfunction. Long non-coding RNAs (lncRNAs) can contribute to cardiomyopathy, but comprehensive mechanistic insights remain elusive. We d...

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Detalhes bibliográficos

Principais autores:	Theresa Hofmann, Sara Hettrich, Bio Maria Ghéo Idrissou, Christian Waechter, Maria Weiss, Salma Hachim, Silke Kreher, Maximilian Staps, Laia Cañes Esteve, Sabine Pankuweit, Hendrik Milting, Mario Looso, Isabelle Marty, Stefan Engelhardt, Thomas Braun, Thomas Boettger
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-07-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-026-75985-8
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