Trdn-as directs m6A-dependent transcriptional termination for accurate triadin isoform switching, preventing aberrant dyads and cardiomyopathy

Abstract Heart failure is a leading cause of mortality, and impaired cardiac excitation-contraction coupling represents a potentially fatal trigger for myocardial dysfunction. Long non-coding RNAs (lncRNAs) can contribute to cardiomyopathy, but comprehensive mechanistic insights remain elusive. We d...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Theresa Hofmann, Sara Hettrich, Bio Maria Ghéo Idrissou, Christian Waechter, Maria Weiss, Salma Hachim, Silke Kreher, Maximilian Staps, Laia Cañes Esteve, Sabine Pankuweit, Hendrik Milting, Mario Looso, Isabelle Marty, Stefan Engelhardt, Thomas Braun, Thomas Boettger
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2026-07-01
Rangatū:	Nature Communications
Urunga tuihono:	https://doi.org/10.1038/s41467-026-75985-8
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!