Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation

Objective: Although individual steps have been characterized, there is little understanding of the overall process whereby glucose co-ordinates the biosynthesis of insulin with its export out of the endoplasmic reticulum (ER) and incorporation into insulin secretory granules (ISGs). Here we investig...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Nancy Sue, Le May Thai, Atsushi Saito, Cierra K. Boyer, Ashleigh M. Fordham, Chenxu Yan, Aimee Davenport, Jiang Tao, Mohammed Bensellam, James Cantley, Yan-Chuan Shi, Samuel B. Stephens, Kazunori Imaizumi, Trevor J. Biden
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2024-01-01
Schriftenreihe:	Molecular Metabolism
Schlagworte:	Pancreatic β-cell Insulin biosynthesis Insulin secretion O-GlcNAcylation ER stress ER-to-Golgi trafficking
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2212877823001795
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