ER Redox Homeostasis Regulates Proinsulin Trafficking and Insulin Granule Formation in the Pancreatic Islet β-Cell

Abstract Defects in the pancreatic β-cell’s secretion system are well-described in type 2 diabetes (T2D) and include impaired proinsulin processing and a deficit in mature insulin-containing secretory granules; however, the cellular mechanisms underlying these defects remain poorly understood. To ad...

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Hlavní autoři:	Kristen E Rohli, Cierra K Boyer, Shelby C Bearrows, Marshall R Moyer, Weston S Elison, Casey J Bauchle, Sandra E Blom, Jianchao Zhang, Yanzhuang Wang, Samuel B Stephens
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Physiological Society 2022-01-01
Edice:	Function
Témata:	endoplasmic reticulum protein folding redox proinsulin trafficking insulin granule formation β-cell function
On-line přístup:	https://journals.physiology.org/doi/10.1093/function/zqac051
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