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Repair or Degrade: the Thermodynamic Dilemma of Cellular Protein Quality-Control

Life is a non-equilibrium phenomenon. Owing to their high free energy content, the macromolecules of life tend to spontaneously react with ambient oxygen and water and turn into more stable inorganic molecules. A similar thermodynamic picture applies to the complex shapes of proteins: While a polype...

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Principais autores: Bruno Fauvet, Mathieu E. Rebeaud, Satyam Tiwari, Paolo De Los Rios, Pierre Goloubinoff
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Molecular Biosciences
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Acceso en liña:https://www.frontiersin.org/articles/10.3389/fmolb.2021.768888/full
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