Metformin attenuates cuprizone-induced mitochondrial dysfunction and senescence-associated changes in primary neuronal cells

Mitochondrial dysfunction and cellular senescence are key features of brain aging and neurodegenerative diseases. Cuprizone (CPZ), a mitochondrial toxin, induces oxidative stress, abnormal lipid metabolism, and iron accumulation in neurons and oligodendrocytes. Here, we investigated whether metformi...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Yeojin Kim, Hyunbum Jeon, Sun-Yeong Gwon, Sehyun Chae, Ji Young Mun
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Japan Society for Cell Biology 2026-05-01
Schriftenreihe:	Cell Structure and Function
Schlagworte:	mitochondria cpz mfn oxidative stress lipofuscin
Online-Zugang:	https://www.jstage.jst.go.jp/article/csf/51/1/51_26019/_html/-char/en
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