Mitotic microhomology-mediated break-induced replication promotes chromoanasynthesis

Abstract Chromoanasynthesis is a form of complex chromosomal rearrangement (CCR) commonly detected in cancers and congenital disorders, but the mechanism underlying its generation remain elusive. Here we develop a single-molecule long-read DNA sequencing approach to characterise ultra-complex mutati...

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Bibliografiske detaljer

Principais autores:	Greg H. P. Ngo, Kez Cleal, Sara Seifan, Vanda Miklos, Szymon A. Barwacz, Brian L. Ruis, Siamak A. Kamranvar, Julia W. Grimstead, Ying Liu, Eric A. Hendrickson, Duncan M. Baird
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2026-03-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-026-70086-y
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