Mitotic microhomology-mediated break-induced replication promotes chromoanasynthesis

Abstract Chromoanasynthesis is a form of complex chromosomal rearrangement (CCR) commonly detected in cancers and congenital disorders, but the mechanism underlying its generation remain elusive. Here we develop a single-molecule long-read DNA sequencing approach to characterise ultra-complex mutati...

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Detalles Bibliográficos

Principais autores:	Greg H. P. Ngo, Kez Cleal, Sara Seifan, Vanda Miklos, Szymon A. Barwacz, Brian L. Ruis, Siamak A. Kamranvar, Julia W. Grimstead, Ying Liu, Eric A. Hendrickson, Duncan M. Baird
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2026-03-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-026-70086-y
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