Cyy-287, a novel pyrimidine-2,4-diamine derivative, efficiently mitigates inflammatory responses, fibrosis, and lipid synthesis in obesity-induced cardiac and hepatic dysfunction

Background Inflammation and metabolic disorders are important factors in the occurrence and development of obesity complications. In this study, we investigated the protective effect and underlying mechanism of a novel pyrimidine-2,4-diamine derivative, Cyy-287, on mice fed a high-fat diet (HFD). Me...

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Huvudupphov:	Jinhuan Ni, Xiaodan Zhang, Huijing Huang, Zefeng Ni, Jianchao Luo, Yunshan Zhong, Min Hui, Zhiguo Liu, Jianchang Qian, Qianwen Zhang
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	PeerJ Inc. 2024-02-01
Serie:	PeerJ
Ämnen:	Cyy-287 Inflammation Obesity complications Ventricular remodeling Hepatic steatosis NF-kB
Länkar:	https://peerj.com/articles/17009.pdf
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