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Emerging Mechanisms Underpinning Neurophysiological Impairments in C9ORF72 Repeat Expansion-Mediated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by degeneration of upper and lower motor neurons and neurons of the prefrontal cortex. The emergence of the C9ORF72 hexanucleotide repeat expansion mutation as the leading genetic cause of ALS and FTD has led to...

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Principais autores: Iris-Stefania Pasniceanu, Manpreet Singh Atwal, Cleide Dos Santos Souza, Laura Ferraiuolo, Matthew R. Livesey
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-12-01
coleção:Frontiers in Cellular Neuroscience
Assuntos:
C9ORF72
neuron
synaptic
excitability
glutamate
physiology
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fncel.2021.784833/full
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