A conserved ER protein prevents lipotoxicity by stimulating the key enzyme in glycerolipid synthesis

Abstract The synthesis of glycerolipid is essential to prevent the toxic effects of excess fatty acids. Glycerolipids are generated by the sequential attachment of acyl-CoA to glycerol by endoplasmic reticulum (ER)-localized acyltransferases, ultimately yielding non-toxic triacylglycerol that can be...

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Autores principales:	Yan Li, Siwei Huang, Lam Shing Chan, Xuesong Li, Ning-Sum To, Xue Zhao, Kwangsek Jung, Xingyu Yang, Yu Chung Tse, Ningyi Xu, Yu Xia, Tom H. Cheung, Jianan Qu, Ho Yi Mak
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-05-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-026-72786-x
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