Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism

Glutathione (GSH) degradation plays an essential role in GSH homeostasis, which regulates cell survival, especially in cancer cells. Among human GSH degradation enzymes, the ChaC2 enzyme acts on GSH to form 5-<span style="font-variant: small-caps;">l</span>-oxoproline and Cys-Gly specifically in the...

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Autori principali:	Yen T. K. Nguyen, Joon Sung Park, Jun Young Jang, Kyung Rok Kim, Tam T. L. Vo, Kyu-Won Kim, Byung Woo Han
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2019-12-01
Serie:	Biomolecules
Soggetti:	breast cancer chac2 enzyme γ-glutamylcyclotransferase gsh degradation x-ray structure redox homeostasis flexible loop
Accesso online:	https://www.mdpi.com/2218-273X/10/1/31
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