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Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism

Glutathione (GSH) degradation plays an essential role in GSH homeostasis, which regulates cell survival, especially in cancer cells. Among human GSH degradation enzymes, the ChaC2 enzyme acts on GSH to form 5-<span style="font-variant: small-caps;">l</span>-oxoproline and Cys-Gly specifically in the...

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Furkejuvvon:
Váldodahkkit: Yen T. K. Nguyen, Joon Sung Park, Jun Young Jang, Kyung Rok Kim, Tam T. L. Vo, Kyu-Won Kim, Byung Woo Han
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: MDPI AG 2019-12-01
Ráidu:Biomolecules
Fáttát:
breast cancer
chac2
enzyme
γ-glutamylcyclotransferase
gsh degradation
x-ray structure
redox homeostasis
flexible loop
Liŋkkat:https://www.mdpi.com/2218-273X/10/1/31
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