Repurposing anti-viral subunit and mRNA vaccines T cell immunity for intratumoral immunotherapy against solid tumors

Abstract Intratumoral (IT) immunotherapy can stimulate the tumor microenvironment and enhance anti-tumor immunity. We investigated IT delivery of three licensed viral vaccines—Shingrix (VZV shingles), Gardasil-9 (HPV), and Spikevax (SARS-CoV-2)—in prevaccinated mice using the murine tumor model TC-1...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Shiv K. Sethi, Claire E. Bradley, Lukas Bialkowski, Yuk Ying Pang, Cynthia D. Thompson, John T. Schiller, Nicolas Çuburu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-04-01
Schriftenreihe:	npj Vaccines
Online-Zugang:	https://doi.org/10.1038/s41541-025-01131-y
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