Intratumoral co‐injection of NK cells and NKG2A‐neutralizing monoclonal antibodies

Abstract NK‐cell reactivity against cancer is conceivably suppressed in the tumor microenvironment by the interaction of the inhibitory receptor NKG2A with the non‐classical MHC‐I molecules HLA‐E in humans or Qa‐1b in mice. We found that intratumoral delivery of NK cells attains significant therapeu...

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Autors principals:	Ignacio Melero, Maria C Ochoa, Carmen Molina, Sandra Sanchez‐Gregorio, Saray Garasa, Carlos Luri‐Rey, Sandra Hervas‐Stubbs, Noelia Casares, Edurne Elizalde, Gabriel Gomis, Assunta Cirella, Pedro Berraondo, Alvaro Teijeira, Maite Alvarez
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2023-10-01
Col·lecció:	EMBO Molecular Medicine
Matèries:	HLA‐E intratumoral immunotherapy NK NKG2A Qa‐1b
Accés en línia:	https://doi.org/10.15252/emmm.202317804
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