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Profilin 1 controls a microglial cytoskeleton checkpoint to prevent senescence and premature synaptic decline

Abstract Profilin 1 (Pfn1) expression decreases significantly in aged human microglia, suggesting that loss of cytoskeletal integrity may trigger microglial senescence and increased synaptic vulnerability. To test this hypothesis, we used an inducible, microglia-specific Pfn1 knockout in adult mice,...

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Furkejuvvon:
Váldodahkkit: Camila Cabral Portugal, Tiago Oliveira Almeida, Joana Tedim-Moreira, Cátia Silva, Teresa Canedo, João Galvão, Ana Magalhães, Teresa Summavielle, Xianshu Bai, Frank Kirchhoff, Boris Rubinstein, Irina Moreira, Jéssica Costa, Joana Guedes, Inês Mendes Pinto, João Peça, Renato Socodato, João Bettencourt Relvas
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2025-11-01
Ráidu:Journal of Neuroinflammation
Liŋkkat:https://doi.org/10.1186/s12974-025-03588-z
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