A comprehensive computational study to explore promising natural bioactive compounds targeting glycosyltransferase MurG in Escherichia coli for potential drug development

Abstract Peptidoglycan is a carbohydrate with a cross-linked structure that protects the cytoplasmic membrane of bacterial cells from damage. The mechanism of peptidoglycan biosynthesis involves the main synthesizing enzyme glycosyltransferase MurG, which is known as a potential target for antibioti...

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Autori principali:	Amneh Shtaiwi, Shafi Ullah Khan, Meriem Khedraoui, Mohd Alaraj, Abdelouahid Samadi, Samir Chtita
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2024-03-01
Serie:	Scientific Reports
Soggetti:	MurG Natural products Antibacterial Antibiotics resistance Virtual screening Molecular dynamics
Accesso online:	https://doi.org/10.1038/s41598-024-57702-x
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