Anti-inflammatory effect of fluvastatin on polarized macrophages and its dependence on the mevalonate pathway

Abstract The study focuses on the effects of fluvastatin on immunomarkers of the M1 and M2 macrophages and its direct role in macrophage (M0) polarization. Moreover, it investigates the dependency of immunomodulatory properties of fluvastatin on the mevalonate pathway. Macrophages (M0, M1, M2), diff...

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Hlavní autoři:	Barbora Muffova, Sona Kauerova, Karel Paukner, Hana Bartuskova, Rudolf Poledne, Ivana Kralova Lesna
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-06-01
Edice:	Scientific Reports
Témata:	Fluvastatin Macrophages Polarization Inflammation Mevalonate pathway
On-line přístup:	https://doi.org/10.1038/s41598-025-02418-9
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