Anti-inflammatory effect of fluvastatin on polarized macrophages and its dependence on the mevalonate pathway

Abstract The study focuses on the effects of fluvastatin on immunomarkers of the M1 and M2 macrophages and its direct role in macrophage (M0) polarization. Moreover, it investigates the dependency of immunomodulatory properties of fluvastatin on the mevalonate pathway. Macrophages (M0, M1, M2), diff...

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Detalhes bibliográficos

Principais autores:	Barbora Muffova, Sona Kauerova, Karel Paukner, Hana Bartuskova, Rudolf Poledne, Ivana Kralova Lesna
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-06-01
coleção:	Scientific Reports
Assuntos:	Fluvastatin Macrophages Polarization Inflammation Mevalonate pathway
Acesso em linha:	https://doi.org/10.1038/s41598-025-02418-9
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