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Synergistic Effects of Multi-Kinase Inhibition on <i>LRRK2</i>-G2019S and Alpha-Synuclein Pathologies in Models of Parkinson’s Disease

<b>Introduction</b>: Pathogenic mutations in leucine-rich repeat protein kinase-2 (<i>LRRK2</i>), particularly G2019S, constitute the most common cause of autosomal dominant PD. <b>Methods</b>: Mouse models encoding human mutant alpha-synuclein (<i>SNCA A53T</i>) and <i>LRRK2</i> G2019S were treated...

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Principais autores: Xiaoguang Liu, Sean Baxley, Michaeline L. Hebron, Charbel Moussa
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-04-01
Serier:Biomedicines
Fag:
Parkinson’s disease
alpha-synuclein
LRRK2
dopamine
tyrosine kinase inhibition
Online adgang:https://www.mdpi.com/2227-9059/14/4/927
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